Title |
A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (Part I – Protection via specific pathways)
|
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Published in |
Medical Gas Research, May 2014
|
DOI | 10.1186/2045-9912-4-9 |
Pubmed ID | |
Authors |
Dustin B Mangus, Lei Huang, Patricia M Applegate, Jason W Gatling, John Zhang, Richard L Applegate |
Abstract |
Neurocognitive deficits are a major source of morbidity in survivors of cardiac arrest. Treatment options that could be implemented either during cardiopulmonary resuscitation or after return of spontaneous circulation to improve these neurological deficits are limited. We conducted a literature review of treatment protocols designed to evaluate neurologic outcome and survival following cardiac arrest with associated global cerebral ischemia. The search was limited to investigational therapies that were utilized to treat global cerebral ischemia associated with cardiac arrest. In this review we discuss potential mechanisms of neurologic protection following cardiac arrest including actions of several medical gases such as xenon, argon, and nitric oxide. The 3 included mechanisms are: 1. Modulation of neuronal cell death; 2. Alteration of oxygen free radicals; and 3. Improving cerebral hemodynamics. Only a few approaches have been evaluated in limited fashion in cardiac arrest patients and results show inconclusive neuroprotective effects. Future research focusing on combined neuroprotective strategies that target multiple pathways are compelling in the setting of global brain ischemia resulting from cardiac arrest. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 59 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Postgraduate | 11 | 18% |
Student > Master | 7 | 12% |
Researcher | 6 | 10% |
Professor > Associate Professor | 6 | 10% |
Student > Ph. D. Student | 5 | 8% |
Other | 18 | 30% |
Unknown | 7 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 42% |
Neuroscience | 6 | 10% |
Agricultural and Biological Sciences | 4 | 7% |
Nursing and Health Professions | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 5 | 8% |
Unknown | 15 | 25% |