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siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells

Overview of attention for article published in Molecular Cancer, May 2009
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Citations

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Readers on

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39 Mendeley
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Title
siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells
Published in
Molecular Cancer, May 2009
DOI 10.1186/1476-4598-8-28
Pubmed ID
Authors

Dae Won Kim, Kyung-Ok Kim, Mike J Shin, Jung Hee Ha, Sung Wook Seo, Jay Yang, Francis Y Lee

Abstract

High expression of P-glycoprotein is one of the well-known mechanisms of chemoresistance in chondrosarcomas. However, the role of antiapoptotic proteins, a common mechanism responsible for chemoresistance in other tumors, has not been well studied in chondrosarcomas. We examined the importance of P-glycoprotein and antiapoptotic proteins in the chemoresistance to doxorubicin of two Grade II chondrosarcoma cell lines, JJ012 and SW1353.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 3%
United States 1 3%
Unknown 37 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 26%
Researcher 7 18%
Student > Master 6 15%
Student > Doctoral Student 5 13%
Student > Bachelor 2 5%
Other 2 5%
Unknown 7 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 23%
Medicine and Dentistry 9 23%
Biochemistry, Genetics and Molecular Biology 7 18%
Chemistry 3 8%
Engineering 2 5%
Other 2 5%
Unknown 7 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2009.
All research outputs
#15,233,109
of 22,649,029 outputs
Outputs from Molecular Cancer
#1,036
of 1,711 outputs
Outputs of similar age
#77,551
of 92,142 outputs
Outputs of similar age from Molecular Cancer
#5
of 5 outputs
Altmetric has tracked 22,649,029 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,711 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 92,142 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.