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Targeted therapy: resistance and re‐sensitization

Overview of attention for article published in Cancer Communications, September 2015
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Targeted therapy: resistance and re‐sensitization
Published in
Cancer Communications, September 2015
DOI 10.1186/s40880-015-0047-1
Pubmed ID

Dao-Hong Chen, Xiao-Shi Zhang


The last two decades have witnessed a paradigm shift from cytotoxic drugs to targeted therapy in medical oncology and pharmaceutical innovation. Inspired by breakthroughs in molecular and cellular biology, a number of novel synthesized chemical compounds and recombinant antibodies have been developed to selectively target oncogenic signaling pathways in a broad array of tumor types. Although targeted therapeutic agents show impressive clinical efficacy and minimized adverse effects compared with traditional treatments, the challenging drug-resistant issue has also emerged to limit their benefits to cancer patients. In this regard, we aim to improve targeted therapy by presenting a systematic framework regarding the drug resistance mechanisms and alternative approaches to re-sensitize cancer cells/tissues therapeutically.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 22%
Student > Master 6 17%
Student > Bachelor 3 8%
Student > Ph. D. Student 3 8%
Student > Doctoral Student 2 6%
Other 5 14%
Unknown 9 25%
Readers by discipline Count As %
Medicine and Dentistry 7 19%
Agricultural and Biological Sciences 6 17%
Biochemistry, Genetics and Molecular Biology 4 11%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Psychology 2 6%
Other 5 14%
Unknown 10 28%