Title |
Targeted therapy: resistance and re‐sensitization
|
---|---|
Published in |
Cancer Communications, September 2015
|
DOI | 10.1186/s40880-015-0047-1 |
Pubmed ID | |
Authors |
Dao-Hong Chen, Xiao-Shi Zhang |
Abstract |
The last two decades have witnessed a paradigm shift from cytotoxic drugs to targeted therapy in medical oncology and pharmaceutical innovation. Inspired by breakthroughs in molecular and cellular biology, a number of novel synthesized chemical compounds and recombinant antibodies have been developed to selectively target oncogenic signaling pathways in a broad array of tumor types. Although targeted therapeutic agents show impressive clinical efficacy and minimized adverse effects compared with traditional treatments, the challenging drug-resistant issue has also emerged to limit their benefits to cancer patients. In this regard, we aim to improve targeted therapy by presenting a systematic framework regarding the drug resistance mechanisms and alternative approaches to re-sensitize cancer cells/tissues therapeutically. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 22% |
Student > Master | 6 | 17% |
Student > Bachelor | 3 | 8% |
Student > Ph. D. Student | 3 | 8% |
Student > Doctoral Student | 2 | 6% |
Other | 5 | 14% |
Unknown | 9 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 19% |
Agricultural and Biological Sciences | 6 | 17% |
Biochemistry, Genetics and Molecular Biology | 4 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Psychology | 2 | 6% |
Other | 5 | 14% |
Unknown | 10 | 28% |