Title |
Mining the pre-diagnostic antibody repertoire of TgMMTV-neu mice to identify autoantibodies useful for the early detection of human breast cancer
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Published in |
Journal of Translational Medicine, May 2014
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DOI | 10.1186/1479-5876-12-121 |
Pubmed ID | |
Authors |
Jianning Mao, Jon Ladd, Ekram Gad, Lauren Rastetter, Melissa M Johnson, Edmond Marzbani, Jennifer S Childs, Hailing Lu, Yushe Dang, Elizabeth Broussard, Sasha E Stanton, Sam M Hanash, Mary L Disis |
Abstract |
The use of autoantibodies for the early detection of breast cancer has generated much interest as antibodies can be readily assayed in serum when antigen levels are low. Ideally, diagnostic autoantibodies would be identified in individuals who harbored pre-invasive disease/high risk lesions leading to malignancy. Prospectively collected human serum samples from these individuals are rare and not often available for biomarker discovery. We questioned whether transgenic animals could be used to identify cancer-associated autoantibodies present at the earliest stages of the malignant transformation of breast cancer. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 7 | 23% |
Student > Ph. D. Student | 6 | 20% |
Researcher | 6 | 20% |
Lecturer | 2 | 7% |
Student > Doctoral Student | 1 | 3% |
Other | 3 | 10% |
Unknown | 5 | 17% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 6 | 20% |
Medicine and Dentistry | 3 | 10% |
Nursing and Health Professions | 2 | 7% |
Unspecified | 1 | 3% |
Other | 2 | 7% |
Unknown | 5 | 17% |