Title |
The indole-3-carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor-positive and triple-negative breast cancer cell lines
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Published in |
Breast Cancer Research, March 2011
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DOI | 10.1186/bcr2855 |
Pubmed ID | |
Authors |
Mauro De Santi, Luca Galluzzi, Simone Lucarini, Maria Filomena Paoletti, Alessandra Fraternale, Andrea Duranti, Cinzia De Marco, Mirco Fanelli, Nadia Zaffaroni, Giorgio Brandi, Mauro Magnani |
Abstract |
Indole-3-carbinol (I3C), an autolysis product of glucosinolates present in cruciferous vegetables, and its dimeric derivative (3,3'-DIM) have been indicated as promising agents in preventing the development and progression of breast cancer. We have recently shown that I3C cyclic tetrameric derivative CTet formulated in γ-cyclodextrin (γ-CD) efficiently inhibited cellular proliferation in breast cancer cell lines. This study aims to analyze the mechanisms involved in the in vitro inhibition of cell proliferation and to evaluate the in vivo antitumor activity of CTet in a xenograft study. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Belgium | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 3% |
Croatia | 1 | 3% |
India | 1 | 3% |
Unknown | 37 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 20% |
Researcher | 7 | 18% |
Student > Master | 6 | 15% |
Student > Postgraduate | 3 | 8% |
Student > Bachelor | 3 | 8% |
Other | 6 | 15% |
Unknown | 7 | 18% |
Readers by discipline | Count | As % |
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Chemistry | 6 | 15% |
Agricultural and Biological Sciences | 6 | 15% |
Biochemistry, Genetics and Molecular Biology | 5 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Other | 0 | 0% |
Unknown | 11 | 28% |