Title |
Direct effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma
|
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Published in |
Journal of Experimental & Clinical Cancer Research, May 2014
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DOI | 10.1186/1756-9966-33-41 |
Pubmed ID | |
Authors |
Ruijin Shao, Xin Li, Yi Feng, Jin-Fang Lin, Håkan Billig |
Abstract |
Although a number of in vitro studies have demonstrated the antiproliferative, anti-invasive, and antimetastatic effects of metformin in multiple cancer cell types, its cellular and molecular mechanisms of anti-cancer action in the endometrium of women with polycystic ovary syndrome (PCOS) have not yet been fully elucidated. Organic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs) are known to be involved in metformin uptake and excretion in cells. In this article, we discuss the novel therapeutic possibilities for early-stage endometrial carcinoma (EC) in women with PCOS focusing on metformin, which might have a direct effect in the endometrium through the OCTs and MATEs. We then review the molecular mechanism(s) of the action of metformin in the endometrium and highlight possible mechanistic insights into the inhibition of cell proliferation and tumor growth and, ultimately, the reversal of early-stage EC into normal endometria in women with PCOS. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Indonesia | 1 | 1% |
Mexico | 1 | 1% |
United States | 1 | 1% |
Unknown | 73 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 14 | 18% |
Researcher | 12 | 16% |
Student > Master | 10 | 13% |
Student > Ph. D. Student | 5 | 7% |
Professor > Associate Professor | 5 | 7% |
Other | 14 | 18% |
Unknown | 16 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 30 | 39% |
Biochemistry, Genetics and Molecular Biology | 9 | 12% |
Agricultural and Biological Sciences | 9 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Nursing and Health Professions | 3 | 4% |
Other | 2 | 3% |
Unknown | 20 | 26% |