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Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents

Overview of attention for article published in BMC Neuroscience, August 2017
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2 tweeters

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Title
Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents
Published in
BMC Neuroscience, August 2017
DOI 10.1186/s12868-017-0376-x
Pubmed ID
Authors

Jessica A. Waller, Sara Holm Nygaard, Yan Li, Kristian Gaarn du Jardin, Joseph A. Tamm, Aicha Abdourahman, Betina Elfving, Alan L. Pehrson, Connie Sánchez, Rasmus Wernersson

Abstract

The identification of biomarkers that predict susceptibility to major depressive disorder and treatment response to antidepressants is a major challenge. Vortioxetine is a novel multimodal antidepressant that possesses pro-cognitive properties and differentiates from other conventional antidepressants on various cognitive and plasticity measures. The aim of the present study was to identify biological systems rather than single biomarkers that may underlie vortioxetine's treatment effects. We show that the biological systems regulated by vortioxetine are overlapping between mouse and rat in response to distinct treatment regimens and in different brain regions. Furthermore, analysis of complexes of physically-interacting proteins reveal that biomarkers involved in transcriptional regulation, neurodevelopment, neuroplasticity, and endocytosis are modulated by vortioxetine. A subsequent qPCR study examining the expression of targets in the protein-protein interactome space in response to chronic vortioxetine treatment over a range of doses provides further biological validation that vortioxetine engages neuroplasticity networks. Thus, the same biology is regulated in different species and sexes, different brain regions, and in response to distinct routes of administration and regimens. A recurring theme, based on the present study as well as previous findings, is that networks related to synaptic plasticity, synaptic transmission, signal transduction, and neurodevelopment are modulated in response to vortioxetine treatment. Regulation of these signaling pathways by vortioxetine may underlie vortioxetine's cognitive-enhancing properties.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 28%
Student > Ph. D. Student 4 14%
Student > Master 2 7%
Professor > Associate Professor 2 7%
Researcher 2 7%
Other 3 10%
Unknown 8 28%
Readers by discipline Count As %
Medicine and Dentistry 5 17%
Pharmacology, Toxicology and Pharmaceutical Science 3 10%
Biochemistry, Genetics and Molecular Biology 2 7%
Engineering 2 7%
Neuroscience 2 7%
Other 5 17%
Unknown 10 34%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 August 2017.
All research outputs
#12,869,332
of 20,754,226 outputs
Outputs from BMC Neuroscience
#584
of 1,201 outputs
Outputs of similar age
#154,567
of 287,572 outputs
Outputs of similar age from BMC Neuroscience
#2
of 3 outputs
Altmetric has tracked 20,754,226 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,201 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,572 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.