Title |
The Escherichia coli uropathogenic-specific-protein-associated immunity protein 3 (Imu3) has nucleic acid -binding activity
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Published in |
BMC Microbiology, January 2014
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DOI | 10.1186/1471-2180-14-16 |
Pubmed ID | |
Authors |
Miha Črnigoj, Zdravko Podlesek, Maruška Budič, Darja Žgur-Bertok |
Abstract |
The Escherichia coli uropathogenic-specific protein (Usp) is a bacteriocin-like genotoxin, active against mammalian cells and associated with E. coli strains that provoke pyelonephritis, prostatitis and bacteraemia. Usp is encoded by a small pathogenicity island with three downstream small open reading frames (Imu1-3) that are believed to provide immunity to the producer. To prevent host suicide, colicins, bacteriocins of E. coli, form tight complexes with their cognate immunity proteins. Colicin - immunity protein complexes are among the strongest protein complexes known. Here, the Usp associated immunity protein 3 (Imu3) was partially characterized to gain insight into its role and mechanism of activity. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 27% |
Other | 4 | 12% |
Student > Bachelor | 4 | 12% |
Student > Doctoral Student | 3 | 9% |
Student > Master | 3 | 9% |
Other | 3 | 9% |
Unknown | 7 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 24% |
Agricultural and Biological Sciences | 8 | 24% |
Immunology and Microbiology | 4 | 12% |
Veterinary Science and Veterinary Medicine | 2 | 6% |
Environmental Science | 1 | 3% |
Other | 2 | 6% |
Unknown | 8 | 24% |