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X Demographics
Mendeley readers
| Title |
Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile
|
|---|---|
| Published in |
BMC Biology, May 2014
|
| DOI | 10.1186/1741-7007-12-32 |
| Pubmed ID | |
| Authors |
Catherine Reynolds, Deborah Chong, Eleanor Raynsford, Kathryn Quigley, Deborah Kelly, Julia Llewellyn-Hughes, Daniel Altmann, Rosemary Boyton |
| Abstract |
CD4 T lymphocyte activation requires T cell receptor (TCR) engagement by peptide/MHC (major histocompatibility complex) (pMHC). The TCR complementarity-determining region 3 (CDR3) contains variable α and β loops critical for pMHC recognition. During any immune response, tuning of TCR usage through progressive clonal selection occurs. Th1 and Th2 cells operate at different avidities for activation and display distinct transcriptional programs, although polarization may be plastic, influenced by pathogens and cytokines. We therefore hypothesized that CDR3αβ sequence features may intrinsically influence CD4 phenotype during progression of a response. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Czechia | 1 | 4% |
| Belgium | 1 | 4% |
| Unknown | 21 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 22% |
| Researcher | 5 | 22% |
| Student > Master | 4 | 17% |
| Student > Postgraduate | 3 | 13% |
| Professor | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 2 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 26% |
| Biochemistry, Genetics and Molecular Biology | 5 | 22% |
| Immunology and Microbiology | 5 | 22% |
| Medicine and Dentistry | 2 | 9% |
| Sports and Recreations | 2 | 9% |
| Other | 1 | 4% |
| Unknown | 2 | 9% |