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Mendeley readers
| Title |
Response to imatinib in villonodular pigmented synovitis (PVNS) resistant to nilotinib
|
|---|---|
| Published in |
Clinical Sarcoma Research, May 2013
|
| DOI | 10.1186/2045-3329-3-8 |
| Pubmed ID | |
| Authors |
Silvia Stacchiotti, Flavio Crippa, Antonella Messina, Silvana Pilotti, Alessandro Gronchi, Jean Y Blay, Paolo G Casali |
| Abstract |
Pigmented villonodular synovitis (PVNS) is a rare locally aggressive tumor. PVNS is characterized in most cases by a specific t(1;2) translocation, which fuses the colony stimulating factor-1 (CSF1) gene to the collagen type VIa3 (COL6A3) promoter thus leading through a paracrine effect to the attraction of non-neoplastic inflammatory cells expressing CSF1-receptor. Imatinib is a tirosin-kinase inhibitors (TKI) active against CSF1-receptor whose activity in naïve PVNS was already described. We report on two PVNS patients who responded to imatinib after failure to nilotinib, another CSF1-receptor inhibitor. |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 4% |
| Italy | 1 | 4% |
| Luxembourg | 1 | 4% |
| Unknown | 20 | 87% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 5 | 22% |
| Student > Ph. D. Student | 4 | 17% |
| Researcher | 3 | 13% |
| Student > Doctoral Student | 2 | 9% |
| Professor | 2 | 9% |
| Other | 5 | 22% |
| Unknown | 2 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 65% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Computer Science | 1 | 4% |
| Agricultural and Biological Sciences | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 4 | 17% |