Title |
New insights into the role of ID proteins in breast cancer metastasis: a MET affair
|
---|---|
Published in |
Breast Cancer Research, May 2014
|
DOI | 10.1186/bcr3654 |
Pubmed ID | |
Authors |
Wee Siang Teo, Radhika Nair, Alexander Swarbrick |
Abstract |
The establishment of lethal metastases depends on the capacity of a small number of cancer cells to regenerate a tumor after entering a target organ. Stankic and colleagues have identified a role for the inhibitor of differentiation protein, ID1, as a critical regulator of breast cancer stem-like properties and metastatic colonization. Under the control of tumor growth factor-beta signaling, ID1 induces mesenchymal-epithelial transition at the metastatic site by antagonizing the activity of the basic helix-loop-helix transcription factor Twist1. This study sheds light on mechanisms that initiate metastatic outgrowth, and strengthens the concept that epithelial-mesenchymal plasticity is crucial at different stages of metastasis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Luxembourg | 1 | 7% |
Unknown | 14 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 33% |
Student > Master | 3 | 20% |
Student > Bachelor | 2 | 13% |
Researcher | 2 | 13% |
Professor > Associate Professor | 1 | 7% |
Other | 0 | 0% |
Unknown | 2 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 33% |
Biochemistry, Genetics and Molecular Biology | 3 | 20% |
Medicine and Dentistry | 3 | 20% |
Neuroscience | 1 | 7% |
Chemistry | 1 | 7% |
Other | 0 | 0% |
Unknown | 2 | 13% |