Title |
Not all the number of skeletal muscle fibers is determined prenatally
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Published in |
BMC Developmental Biology, November 2015
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DOI | 10.1186/s12861-015-0091-8 |
Pubmed ID | |
Authors |
Mingsen Li, Xingyu Zhou, Yaosheng Chen, Yaping Nie, Huaxing Huang, Hu Chen, Delin Mo |
Abstract |
The investigation of skeletal muscle development is of importance in stock farming and biomedicine. It is still ambiguous that whether animals are born with the full set of skeletal muscle fibers or if the number of myofibers continues to increase postnatally. Here, an inducible lineage-tracing system was employed to monitor the changes of myofiber number in various skeletal muscles during development. We confirm that the total myofiber number of longissimus dorsi, gastrocnemius and rectus femoris is determined prenatally. However, tibialis anterior and extensor digitorum longus have a different development pattern, and their myofiber number still increases in the first postnatal week and then remains stable afterwards. Our results highlight different development time frames of anatomically distinct skeletal muscles. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 23% |
Student > Ph. D. Student | 6 | 17% |
Student > Doctoral Student | 5 | 14% |
Student > Master | 4 | 11% |
Student > Bachelor | 3 | 9% |
Other | 2 | 6% |
Unknown | 7 | 20% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 8 | 23% |
Medicine and Dentistry | 7 | 20% |
Sports and Recreations | 5 | 14% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Neuroscience | 2 | 6% |
Other | 2 | 6% |
Unknown | 9 | 26% |