Title |
Vorinostat positively regulates synaptic plasticity genes expression and spine density in HIV infected neurons: role of nicotine in progression of HIV-associated neurocognitive disorder
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Published in |
Molecular Brain, May 2014
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DOI | 10.1186/1756-6606-7-37 |
Pubmed ID | |
Authors |
Venkata Subba Rao Atluri, Sudheesh Pilakka-Kanthikeel, Thangavel Samikkannu, Vidya Sagar, Kesava Rao Venkata Kurapati, Shailendra K Saxena, Adriana Yndart, Andrea Raymond, Hong Ding, Oscar Hernandez, Madhavan PN Nair |
Abstract |
HIV-associated neurocognitive disorder (HAND) is characterized by development of cognitive, behavioral and motor abnormalities, and occurs in approximately 50% of HIV infected individuals. In the United States, the prevalence of cigarette smoking ranges from 35-70% in HIV-infected individuals compared to 20% in general population. Cognitive impairment in heavy cigarette smokers has been well reported. However, the synergistic effects of nicotine and HIV infection and the underlying mechanisms in the development of HAND are unknown. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 25% |
United States | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 49 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 14% |
Researcher | 6 | 12% |
Student > Bachelor | 5 | 10% |
Student > Ph. D. Student | 5 | 10% |
Other | 3 | 6% |
Other | 8 | 16% |
Unknown | 15 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 7 | 14% |
Biochemistry, Genetics and Molecular Biology | 4 | 8% |
Agricultural and Biological Sciences | 4 | 8% |
Psychology | 4 | 8% |
Medicine and Dentistry | 4 | 8% |
Other | 10 | 20% |
Unknown | 16 | 33% |