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Very small size proteoliposomes abrogate cross-presentation of tumor antigens by myeloid-derived suppressor cells and induce their differentiation to dendritic cells

Overview of attention for article published in Journal for Immunotherapy of Cancer, March 2014
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1 tweeter

Citations

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7 Dimensions

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29 Mendeley
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Title
Very small size proteoliposomes abrogate cross-presentation of tumor antigens by myeloid-derived suppressor cells and induce their differentiation to dendritic cells
Published in
Journal for Immunotherapy of Cancer, March 2014
DOI 10.1186/2051-1426-2-5
Pubmed ID
Authors

Audry Fernández, Liliana Oliver, Rydell Alvarez, Arletty Hernández, Judith Raymond, Luis E Fernández, Circe Mesa

Abstract

Myeloid-derived suppressor cells (MDSCs) are among the major obstacles that adjuvants for cancer vaccines have to overcome. These cells cross-present tumor-associated antigens (TAA) to naive T lymphocytes with a tolerogenic outcome. Very Small Size Proteoliposomes (VSSP) is used as adjuvant by four therapeutic cancer vaccines currently in Phase I and II clinical trials. We previously found that VSSP reduces the suppressive function of MDSCs, then activating antigen-specific CTL responses in tumor-bearing (TB) mice, with the consequent reduction of tumor growth. However the mechanistic explanation for the immunomodulatory effect of this adjuvant in TB hosts has not been addressed before.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 3%
United States 1 3%
Unknown 27 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 34%
Student > Ph. D. Student 6 21%
Student > Bachelor 4 14%
Student > Master 2 7%
Professor 1 3%
Other 2 7%
Unknown 4 14%
Readers by discipline Count As %
Immunology and Microbiology 6 21%
Agricultural and Biological Sciences 6 21%
Medicine and Dentistry 3 10%
Biochemistry, Genetics and Molecular Biology 2 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Other 5 17%
Unknown 5 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2014.
All research outputs
#2,471,801
of 4,655,094 outputs
Outputs from Journal for Immunotherapy of Cancer
#112
of 175 outputs
Outputs of similar age
#54,547
of 109,677 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#9
of 9 outputs
Altmetric has tracked 4,655,094 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 175 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 109,677 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one.