Title |
Distinguishing West Nile virus infection using a recombinant envelope protein with mutations in the conserved fusion-loop
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Published in |
BMC Infectious Diseases, May 2014
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DOI | 10.1186/1471-2334-14-246 |
Pubmed ID | |
Authors |
Stefan Chabierski, Luisa Barzon, Anna Papa, Matthias Niedrig, Jonathan L Bramson, Justin M Richner, Giorgio Palù, Michael S Diamond, Sebastian Ulbert |
Abstract |
West Nile Virus (WNV) is an emerging mosquito-transmitted flavivirus that continues to spread and cause disease throughout several parts of the world, including Europe and the Americas. Specific diagnosis of WNV infections using current serological testing is complicated by the high degree of cross-reactivity between antibodies against other clinically relevant flaviviruses, including dengue, tick-borne encephalitis (TBEV), Japanese encephalitis (JEV), and yellow fever (YFV) viruses. Cross-reactivity is particularly problematic in areas where different flaviviruses co-circulate or in populations that have been immunized with vaccines against TBEV, JEV, or YFV. The majority of cross-reactive antibodies against the immunodominant flavivirus envelope (E) protein target a conserved epitope in the fusion loop at the distal end of domain II. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 3% |
United States | 1 | 1% |
Unknown | 65 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 19% |
Student > Ph. D. Student | 12 | 18% |
Student > Bachelor | 8 | 12% |
Student > Doctoral Student | 6 | 9% |
Student > Master | 6 | 9% |
Other | 9 | 13% |
Unknown | 14 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 21% |
Biochemistry, Genetics and Molecular Biology | 11 | 16% |
Medicine and Dentistry | 8 | 12% |
Immunology and Microbiology | 8 | 12% |
Veterinary Science and Veterinary Medicine | 5 | 7% |
Other | 8 | 12% |
Unknown | 14 | 21% |