Title |
Structural evolution of CatSper1 in rodents is influenced by sperm competition, with effects on sperm swimming velocity
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Published in |
BMC Ecology and Evolution, May 2014
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DOI | 10.1186/1471-2148-14-106 |
Pubmed ID | |
Authors |
Alberto Vicens, Maximiliano Tourmente, Eduardo RS Roldan |
Abstract |
Competition between spermatozoa from rival males for success in fertilization (i.e., sperm competition) is an important selective force driving the evolution of male reproductive traits and promoting positive selection in genes related to reproductive function. Positive selection has been identified in reproductive proteins showing rapid divergence at nucleotide level. Other mutations, such as insertions and deletions (indels), also occur in protein-coding sequences. These structural changes, which exist in reproductive genes and result in length variation in coded proteins, could also be subjected to positive selection and be under the influence of sperm competition. Catsper1 is one such reproductive gene coding for a germ-line specific voltage-gated calcium channel essential for sperm motility and fertilization. Positive selection appears to promote fixation of indels in the N-terminal region of CatSper1 in mammalian species. However, it is not known which selective forces underlie these changes and their implications for sperm function. |
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