Title |
Peripheral Nerve Injury and TRPV1-Expressing Primary Afferent C-Fibers Cause Opening of the Blood-Brain Barrier
|
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Published in |
Molecular Pain, January 2010
|
DOI | 10.1186/1744-8069-6-74 |
Pubmed ID | |
Authors |
Simon Beggs, Xue Jun Liu, Chun Kwan, Michael W Salter |
Abstract |
The blood-brain barrier (BBB) plays the crucial role of limiting exposure of the central nervous system (CNS) to damaging molecules and cells. Dysfunction of the BBB is critical in a broad range of CNS disorders including neurodegeneration, inflammatory or traumatic injury to the CNS, and stroke. In peripheral tissues, the vascular-tissue permeability is normally greater than BBB permeability, but vascular leakage can be induced by efferent discharge activity in primary sensory neurons leading to plasma extravasation into the extravascular space. Whether discharge activity of sensory afferents entering the CNS may open the BBB or blood-spinal cord barrier (BSCB) remains an open question. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 2 | 33% |
Norway | 1 | 17% |
Canada | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
Chile | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
Unknown | 153 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 27 | 17% |
Researcher | 27 | 17% |
Student > Master | 20 | 13% |
Student > Bachelor | 16 | 10% |
Other | 10 | 6% |
Other | 32 | 20% |
Unknown | 25 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 35 | 22% |
Neuroscience | 33 | 21% |
Agricultural and Biological Sciences | 21 | 13% |
Biochemistry, Genetics and Molecular Biology | 11 | 7% |
Nursing and Health Professions | 8 | 5% |
Other | 19 | 12% |
Unknown | 30 | 19% |