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Examining non-LTR retrotransposons in the context of the evolving primate brain

Overview of attention for article published in BMC Biology, August 2017
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Title
Examining non-LTR retrotransposons in the context of the evolving primate brain
Published in
BMC Biology, August 2017
DOI 10.1186/s12915-017-0409-z
Pubmed ID
Authors

Sara B. Linker, Maria C. Marchetto, Iñigo Narvaiza, Ahmet M. Denli, Fred H. Gage

Abstract

Researchers have long sought to understand the genetic basis of the cognitive differences between primates, with particular focus on the human brain. Although all mutational types have worked in concert with evolutionary forces to generate the current human brain, in this review we will explore the impact of mobile elements, specifically non-LTR retrotransposons. Non-LTR retrotransposons have contributed coding and regulatory sequences to the genome throughout evolution. During primate evolution there have been multiple waves of LINE retrotransposition as well as the birth of new mobile elements such as the SINEs Alu and SVA and we will explore what kinds of impacts these may have had on the evolving human brain.

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The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 58 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 21%
Student > Ph. D. Student 11 19%
Student > Master 8 14%
Student > Bachelor 5 9%
Student > Doctoral Student 4 7%
Other 8 14%
Unknown 10 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 21 36%
Agricultural and Biological Sciences 18 31%
Neuroscience 5 9%
Medicine and Dentistry 1 2%
Arts and Humanities 1 2%
Other 0 0%
Unknown 12 21%