Title |
Differential contributory roles of nucleotide excision and homologous recombination repair for enhancing cisplatin sensitivity in human ovarian cancer cells
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Published in |
Molecular Cancer, March 2011
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DOI | 10.1186/1476-4598-10-24 |
Pubmed ID | |
Authors |
Qi-En Wang, Keisha Milum, Chunhua Han, Yi-Wen Huang, Gulzar Wani, Jürgen Thomale, Altaf A Wani |
Abstract |
While platinum-based chemotherapeutic agents are widely used to treat various solid tumors, the acquired platinum resistance is a major impediment in their successful treatment. Since enhanced DNA repair capacity is a major factor in conferring cisplatin resistance, targeting of DNA repair pathways is an effective stratagem for overcoming cisplatin resistance. This study was designed to delineate the role of nucleotide excision repair (NER), the principal mechanism for the removal of cisplatin-induced DNA intrastrand crosslinks, in cisplatin resistance and reveal the impact of DNA repair interference on cisplatin sensitivity in human ovarian cancer cells. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 57 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 22% |
Student > Ph. D. Student | 11 | 19% |
Student > Bachelor | 8 | 14% |
Student > Master | 6 | 10% |
Student > Doctoral Student | 4 | 7% |
Other | 8 | 14% |
Unknown | 9 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 29% |
Medicine and Dentistry | 12 | 20% |
Biochemistry, Genetics and Molecular Biology | 10 | 17% |
Chemistry | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 5 | 8% |
Unknown | 10 | 17% |