Title |
A decrease in aquaporin 2 excretion is associated with bed rest induced high calciuria
|
---|---|
Published in |
Journal of Translational Medicine, May 2014
|
DOI | 10.1186/1479-5876-12-133 |
Pubmed ID | |
Authors |
Grazia Tamma, Annarita Di Mise, Marianna Ranieri, Maria Svelto, Rado Pisot, Giancarlo Bilancio, Pierpaolo Cavallo, Natale G De Santo, Massimo Cirillo, Giovanna Valenti |
Abstract |
Exposure to microgravity or immobilization results in alterations of renal function, fluid redistribution and bone loss, which couples to a rise of urinary calcium excretion. We recently demonstrated that high calcium delivery to the collecting duct reduces local Aquaporin-2 (AQP2) mediated water reabsorption under vasopressin action, thus limiting the maximal urinary concentration and reducing calcium saturation. To investigate renal water balance adaptation during bed rest, a model to mimic the effects of microgravity on earth, the effect of changes in urinary calcium on urinary AQP2 excretion were assessed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 3% |
Unknown | 30 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 6 | 19% |
Researcher | 5 | 16% |
Professor > Associate Professor | 3 | 10% |
Student > Master | 3 | 10% |
Other | 2 | 6% |
Other | 7 | 23% |
Unknown | 5 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 23% |
Agricultural and Biological Sciences | 6 | 19% |
Medicine and Dentistry | 5 | 16% |
Nursing and Health Professions | 1 | 3% |
Psychology | 1 | 3% |
Other | 4 | 13% |
Unknown | 7 | 23% |