Title |
Laminin 411 acts as a potent inducer of umbilical cord mesenchymal stem cell differentiation into insulin-producing cells
|
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Published in |
Journal of Translational Medicine, May 2014
|
DOI | 10.1186/1479-5876-12-135 |
Pubmed ID | |
Authors |
Huiting Qu, Xiaoli Liu, Yihong Ni, Yang Jiang, Xiaoli Feng, Juan Xiao, Yanan Guo, Dexiao Kong, Ai Li, Xiaomei Li, Xianghua Zhuang, Zhilun Wang, Yongjing Wang, Yali Chang, Shihong Chen, Feng Kong, Xuhua Zhang, Shengtian Zhao, Yi Sun, Dawei Xu, Daoqing Wang, Chengyun Zheng |
Abstract |
Diabetes mellitus (DM) is an incurable metabolic disease constituting a major threat to human health. Insulin-producing cells (IPCs) differentiated from mesenchymal stem cells (MSCs) hold great promise in the treatment of DM. The development of an efficient IPC induction system is a crucial step for the clinical application of IPCs for DM. Laminin 411 is a key component of the basement membrane and is involved in the regulation of cell differentiation; however, little is known about a role of laminin 411 in the regulation of IPC differentiation from human MSCs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Sweden | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
United States | 1 | 2% |
Unknown | 57 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 24% |
Researcher | 9 | 15% |
Student > Master | 8 | 14% |
Student > Bachelor | 7 | 12% |
Student > Doctoral Student | 5 | 8% |
Other | 5 | 8% |
Unknown | 11 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 25% |
Agricultural and Biological Sciences | 11 | 19% |
Biochemistry, Genetics and Molecular Biology | 10 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Neuroscience | 2 | 3% |
Other | 7 | 12% |
Unknown | 12 | 20% |