Title |
Baseline predictors of response and discontinuation of tumor necrosis factor-alpha blocking therapy in ankylosing spondylitis: a prospective longitudinal observational cohort study
|
---|---|
Published in |
Arthritis Research & Therapy, June 2011
|
DOI | 10.1186/ar3369 |
Pubmed ID | |
Authors |
Suzanne Arends, Elisabeth Brouwer, Eveline van der Veer, Henk Groen, Martha K Leijsma, Pieternella M Houtman, Tim L Th A Jansen, Cees GM Kallenberg, Anneke Spoorenberg |
Abstract |
Identifying ankylosing spondylitis (AS) patients who are likely to benefit from tumor necrosis factor-alpha (TNF-α) blocking therapy is important, especially in view of the costs and potential side effects of these agents. Recently, the AS Disease Activity Score (ASDAS) has been developed to assess both subjective and objective aspects of AS disease activity. However, data about the predictive value of the ASDAS with respect to clinical response to TNF-α blocking therapy are lacking. The aim of the present study was to identify baseline predictors of response and discontinuation of TNF-α blocking therapy in AS patients in daily clinical practice. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | <1% |
Australia | 1 | <1% |
Finland | 1 | <1% |
Paraguay | 1 | <1% |
Denmark | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 114 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 21 | 17% |
Other | 14 | 12% |
Student > Ph. D. Student | 14 | 12% |
Researcher | 8 | 7% |
Student > Doctoral Student | 8 | 7% |
Other | 27 | 22% |
Unknown | 29 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 49 | 40% |
Immunology and Microbiology | 7 | 6% |
Nursing and Health Professions | 6 | 5% |
Agricultural and Biological Sciences | 4 | 3% |
Neuroscience | 4 | 3% |
Other | 17 | 14% |
Unknown | 34 | 28% |