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Therapeutic potential of a gamma-secretase inhibitor for hearing restoration in a guinea pig model with noise-induced hearing loss

Overview of attention for article published in BMC Neuroscience, May 2014
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  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
2 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
40 Dimensions

Readers on

mendeley
62 Mendeley
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Title
Therapeutic potential of a gamma-secretase inhibitor for hearing restoration in a guinea pig model with noise-induced hearing loss
Published in
BMC Neuroscience, May 2014
DOI 10.1186/1471-2202-15-66
Pubmed ID
Authors

Yosuke Tona, Kiyomi Hamaguchi, Masaaki Ishikawa, Takushi Miyoshi, Norio Yamamoto, Kohei Yamahara, Juichi Ito, Takayuki Nakagawa

Abstract

Notch signaling plays a crucial role in the fate determination of cochlear progenitor cells, hair cells, and supporting cells in the developing cochlea. Recent studies have demonstrated the temporal activation of Notch signaling in damaged mature cochleae, and have demonstrated the induction of new hair cells by pharmacologically inhibiting Notch signaling. The present study aimed to illustrate the feasibility of pharmacologically inhibiting Notch signaling by using a gamma-secretase inhibitor for treating sensorineural hearing loss.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 3%
Norway 1 2%
Unknown 59 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 23%
Student > Master 8 13%
Other 7 11%
Professor > Associate Professor 7 11%
Student > Bachelor 4 6%
Other 13 21%
Unknown 9 15%
Readers by discipline Count As %
Medicine and Dentistry 14 23%
Agricultural and Biological Sciences 11 18%
Biochemistry, Genetics and Molecular Biology 5 8%
Neuroscience 5 8%
Engineering 3 5%
Other 11 18%
Unknown 13 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2014.
All research outputs
#14,196,440
of 22,756,196 outputs
Outputs from BMC Neuroscience
#605
of 1,242 outputs
Outputs of similar age
#119,164
of 226,264 outputs
Outputs of similar age from BMC Neuroscience
#13
of 26 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,242 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,264 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.