Title |
Regional differences in acute corticosterone-induced dendritic remodeling in the rat brain and their behavioral consequences
|
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Published in |
BMC Neuroscience, May 2014
|
DOI | 10.1186/1471-2202-15-65 |
Pubmed ID | |
Authors |
Hyejin Kim, Jee Hyun Yi, Kyuhyun Choi, Seokheon Hong, Ki Soon Shin, Shin Jung Kang |
Abstract |
Glucocorticoid released by stressful stimuli elicits various stress responses. Acute treatment with a single dose of corticosterone (CORT; predominant glucocorticoid of rats) alone has previously been shown to trigger anxiety behavior and robust dendritic hypertrophy of neurons in the basolateral amygdala (BLA). Neurons in the medial prefrontal cortex (mPFC) are also known to be highly sensitive to stress and regulate anxiety-like behaviors. Nevertheless, we know less about acute CORT-induced structural changes of other brain regions and their behavioral outcomes. In addition, the temporal profile of acute CORT effects remains to be examined. The current study investigates time course changes of dendritic architectures in the stress vulnerable brain areas, the BLA and mPFC, and their behavioral consequences after acute treatment with a single dose of CORT. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Mexico | 1 | 1% |
United States | 1 | 1% |
Unknown | 73 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 24 | 32% |
Student > Doctoral Student | 7 | 9% |
Researcher | 6 | 8% |
Student > Master | 5 | 7% |
Other | 4 | 5% |
Other | 15 | 20% |
Unknown | 14 | 19% |
Readers by discipline | Count | As % |
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Neuroscience | 27 | 36% |
Agricultural and Biological Sciences | 10 | 13% |
Psychology | 8 | 11% |
Medicine and Dentistry | 8 | 11% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Other | 3 | 4% |
Unknown | 17 | 23% |