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The effects of diet induced obesity on breast cancer associated pathways in mice deficient in SFRP1

Overview of attention for article published in Molecular Cancer, May 2014
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1 tweeter

Citations

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Title
The effects of diet induced obesity on breast cancer associated pathways in mice deficient in SFRP1
Published in
Molecular Cancer, May 2014
DOI 10.1186/1476-4598-13-117
Pubmed ID
Authors

Kelly J Gauger, Lotfi M Bassa, Elizabeth M Henchey, Josephine Wyman, Jennifer Ser-Dolansky, Akihiko Shimono, Sallie S Schneider

Abstract

Secreted frizzled-related proteins (SFRPs) are a family of proteins that block the Wnt signaling pathway and loss of Sfrp1 expression is observed in breast cancer. The molecular mechanisms by which obesity contributes to breast tumorigenesis are not well defined, but involve increased inflammation. Mice deficient in Sfrp1 show enhanced mammary gland inflammation in response to diet induced obesity (DIO). Furthermore, mammary glands from Sfrp1-/- mice exhibit increased Wnt signaling, decreased cell death responses, and excessive hyper branching. The work described here was initiated to investigate whether obesity exacerbates the aforementioned pathways, as they each play a key roles in the development of breast cancer.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 19%
Professor 5 19%
Researcher 4 15%
Student > Bachelor 2 7%
Student > Ph. D. Student 2 7%
Other 4 15%
Unknown 5 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 41%
Biochemistry, Genetics and Molecular Biology 5 19%
Medicine and Dentistry 4 15%
Environmental Science 1 4%
Unknown 6 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2014.
All research outputs
#2,122,616
of 3,799,733 outputs
Outputs from Molecular Cancer
#277
of 474 outputs
Outputs of similar age
#49,294
of 93,852 outputs
Outputs of similar age from Molecular Cancer
#30
of 48 outputs
Altmetric has tracked 3,799,733 research outputs across all sources so far. This one is in the 25th percentile – i.e., 25% of other outputs scored the same or lower than it.
So far Altmetric has tracked 474 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,852 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.