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Endurance training lowers ribosome density despite increasing ribosome biogenesis markers in rodent skeletal muscle

Overview of attention for article published in BMC Research Notes, August 2017
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  • Good Attention Score compared to outputs of the same age (69th percentile)

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8 tweeters
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2 Facebook pages

Citations

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3 Dimensions

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25 Mendeley
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Title
Endurance training lowers ribosome density despite increasing ribosome biogenesis markers in rodent skeletal muscle
Published in
BMC Research Notes, August 2017
DOI 10.1186/s13104-017-2736-0
Pubmed ID
Authors

Matthew A. Romero, C. Brooks Mobley, Melissa A. Linden, Grace Margaret-Eleanor Meers, Jeffrey S. Martin, Kaelin C. Young, R. Scott Rector, Michael D. Roberts

Abstract

The purpose of this study was to examine if: (a) high sugar/high fat Western diet (WD)-feeding affects skeletal muscle ribosome biogenesis markers in hyperphagic, diabetic-prone Otsuka Long-Evans Tokushima Fatty (OLETF) rats, and (b) 12 weeks of treadmill training rescued potential detriments that WD feeding exerted on these markers. Eight week-old male OLETF rats were fed a low-fat control diet (O-CON, n = 10) or high/sucrose/cholesterol Western diet (WD). At weeks 20-32 of age, WD-fed rats were divided into WD sedentary (O-WD/SED, n = 16), or WD treadmill trained (5 days/week, 60 min/day) (O-WD/EX, n = 10) conditions. Interestingly, total RNA (i.e., ribosome density) was 2.3-fold greater in O-WD/SED versus O-WD/EX rats (p = 0.003) despite levels of upstream binding factor protein, RNA polymerase I protein and pre-45S rRNA being greater in O-WD/EX rats. Ribophagy (USP10 and G3BP1) and TRAMP-exosome rRNA degradation pathway (EXOSC10 and SKIV2L2) proteins were assayed to determine if these pathways were involved with lower ribosome density in O-WD/EX rats. While USP10 was higher in O-CON versus O-WD/SED and O-WD/EX rats (p < 0.001 and p < 0.001, respectively), G3BP1, EXOSC10 and SKIV2L2 did not differ between groups. Nop56 and Ncl mRNAs, ribosome assembly markers, were highest in O-WD/EX rats. However, Fbl mRNA and 28S rRNA, downstream ribosome processing markers, were lowest in O-WD/EX rats. Collectively these data suggest that, in WD-fed rats, endurance training increases select skeletal muscle ribosome biogenesis markers. However, endurance training may reduce muscle ribosome density by interfering with rRNA processing and/or export through mechanisms independent of ribophagy or rRNA degradation.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 16%
Researcher 4 16%
Student > Bachelor 3 12%
Other 2 8%
Lecturer > Senior Lecturer 1 4%
Other 4 16%
Unknown 7 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 36%
Medicine and Dentistry 4 16%
Sports and Recreations 2 8%
Social Sciences 1 4%
Agricultural and Biological Sciences 1 4%
Other 0 0%
Unknown 8 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2017.
All research outputs
#4,084,981
of 15,305,941 outputs
Outputs from BMC Research Notes
#687
of 3,391 outputs
Outputs of similar age
#83,288
of 271,685 outputs
Outputs of similar age from BMC Research Notes
#1
of 1 outputs
Altmetric has tracked 15,305,941 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 3,391 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,685 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them