Title |
GAS5 long non-coding RNA in malignant pleural mesothelioma
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Published in |
Molecular Cancer, May 2014
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DOI | 10.1186/1476-4598-13-119 |
Pubmed ID | |
Authors |
Arun Renganathan, Jelena Kresoja-Rakic, Nohemy Echeverry, Gabriela Ziltener, Bart Vrugt, Isabelle Opitz, Rolf A Stahel, Emanuela Felley-Bosco |
Abstract |
Malignant pleural mesothelioma (MPM) is an aggressive cancer with short overall survival. Long non-coding RNAs (lncRNA) are a class of RNAs more than 200 nucleotides long that do not code for protein and are part of the 90% of the human genome that is transcribed. Earlier experimental studies in mice showed GAS5 (growth arrest specific transcript 5) gene deletion in asbestos driven mesothelioma. GAS5 encodes for a lncRNA whose function is not well known, but it has been shown to act as glucocorticoid receptor decoy and microRNA "sponge". Our aim was to investigate the possible role of the GAS5 in the growth of MPM. |
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Mendeley readers
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