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A novel approach to identify driver genes involved in androgen-independent prostate cancer

Overview of attention for article published in Molecular Cancer, May 2014
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Title
A novel approach to identify driver genes involved in androgen-independent prostate cancer
Published in
Molecular Cancer, May 2014
DOI 10.1186/1476-4598-13-120
Pubmed ID
Authors

Ellyn N Schinke, Victor Bii, Arun Nalla, Dustin T Rae, Laura Tedrick, Gary G Meadows, Grant D Trobridge

Abstract

Insertional mutagenesis screens have been used with great success to identify oncogenes and tumor suppressor genes. Typically, these screens use gammaretroviruses (γRV) or transposons as insertional mutagens. However, insertional mutations from replication-competent γRVs or transposons that occur later during oncogenesis can produce passenger mutations that do not drive cancer progression. Here, we utilized a replication-incompetent lentiviral vector (LV) to perform an insertional mutagenesis screen to identify genes in the progression to androgen-independent prostate cancer (AIPC).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 3%
United States 1 3%
Unknown 31 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 24%
Student > Ph. D. Student 7 21%
Student > Master 4 12%
Student > Bachelor 3 9%
Professor 2 6%
Other 9 27%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 21%
Biochemistry, Genetics and Molecular Biology 5 15%
Computer Science 3 9%
Medicine and Dentistry 3 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Other 7 21%
Unknown 6 18%