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Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis

Overview of attention for article published in Journal of Neuroinflammation, May 2014
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1 tweeter

Citations

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58 Dimensions

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59 Mendeley
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Title
Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis
Published in
Journal of Neuroinflammation, May 2014
DOI 10.1186/1742-2094-11-94
Pubmed ID
Authors

Paola Italiani, Cecilia Carlesi, Paola Giungato, Ilaria Puxeddu, Barbara Borroni, Paola Bossù, Paola Migliorini, Gabriele Siciliano, Diana Boraschi

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease leading to the death of affected individuals within years. The involvement of inflammation in the pathogenesis of neurodegenerative diseases, including ALS, is increasingly recognized but still not well understood. The aim of this study is to evaluate the levels of inflammation-related IL-1 family cytokines (IL-1β, IL-18, IL-33, IL-37) and their endogenous inhibitors (IL-1Ra, sIL-1R2, IL-18BP, sIL-1R4) in patients with sporadic ALS (sALS), METHODS: Sera were collected from 144 patients (125 patients were characterized by disease form, duration, and disability, using the revised ALS functional rating scale (ALSFRS-R) and from 40 matched controls. Cerebrospinal fluid (CSF) was collected from 54 patients with sALS and 65 patients with other non-infectious non-oncogenic diseases as controls. Cytokines and inhibitors were measured by commercial ELISA.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Korea, Republic of 1 2%
United States 1 2%
Netherlands 1 2%
Unknown 56 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 22%
Student > Master 11 19%
Student > Ph. D. Student 7 12%
Student > Doctoral Student 4 7%
Professor > Associate Professor 4 7%
Other 11 19%
Unknown 9 15%
Readers by discipline Count As %
Neuroscience 12 20%
Agricultural and Biological Sciences 8 14%
Biochemistry, Genetics and Molecular Biology 7 12%
Medicine and Dentistry 5 8%
Immunology and Microbiology 3 5%
Other 11 19%
Unknown 13 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2014.
All research outputs
#15,301,167
of 22,756,196 outputs
Outputs from Journal of Neuroinflammation
#1,739
of 2,618 outputs
Outputs of similar age
#132,692
of 226,329 outputs
Outputs of similar age from Journal of Neuroinflammation
#11
of 21 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,618 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,329 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.