Title |
Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis
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Published in |
Journal of Neuroinflammation, May 2014
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DOI | 10.1186/1742-2094-11-94 |
Pubmed ID | |
Authors |
Paola Italiani, Cecilia Carlesi, Paola Giungato, Ilaria Puxeddu, Barbara Borroni, Paola Bossù, Paola Migliorini, Gabriele Siciliano, Diana Boraschi |
Abstract |
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease leading to the death of affected individuals within years. The involvement of inflammation in the pathogenesis of neurodegenerative diseases, including ALS, is increasingly recognized but still not well understood. The aim of this study is to evaluate the levels of inflammation-related IL-1 family cytokines (IL-1β, IL-18, IL-33, IL-37) and their endogenous inhibitors (IL-1Ra, sIL-1R2, IL-18BP, sIL-1R4) in patients with sporadic ALS (sALS), METHODS: Sera were collected from 144 patients (125 patients were characterized by disease form, duration, and disability, using the revised ALS functional rating scale (ALSFRS-R) and from 40 matched controls. Cerebrospinal fluid (CSF) was collected from 54 patients with sALS and 65 patients with other non-infectious non-oncogenic diseases as controls. Cytokines and inhibitors were measured by commercial ELISA. |
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