Title |
Transposon identification using profile HMMs
|
---|---|
Published in |
BMC Genomics, February 2010
|
DOI | 10.1186/1471-2164-11-s1-s10 |
Pubmed ID | |
Authors |
Paul T Edlefsen, Jun S Liu |
Abstract |
Transposons are "jumping genes" that account for large quantities of repetitive content in genomes. They are known to affect transcriptional regulation in several different ways, and are implicated in many human diseases. Transposons are related to microRNAs and viruses, and many genes, pseudogenes, and gene promoters are derived from transposons or have origins in transposon-induced duplication. Modeling transposon-derived genomic content is difficult because they are poorly conserved. Profile hidden Markov models (profile HMMs), widely used for protein sequence family modeling, are rarely used for modeling DNA sequence families. The algorithm commonly used to estimate the parameters of profile HMMs, Baum-Welch, is prone to prematurely converge to local optima. The DNA domain is especially problematic for the Baum-Welch algorithm, since it has only four letters as opposed to the twenty residues of the amino acid alphabet. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 4 | 13% |
Brazil | 2 | 6% |
Canada | 1 | 3% |
Denmark | 1 | 3% |
Egypt | 1 | 3% |
Unknown | 23 | 72% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 14 | 44% |
Student > Ph. D. Student | 5 | 16% |
Student > Master | 5 | 16% |
Professor > Associate Professor | 2 | 6% |
Professor | 1 | 3% |
Other | 3 | 9% |
Unknown | 2 | 6% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 25 | 78% |
Computer Science | 3 | 9% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Neuroscience | 1 | 3% |
Unknown | 2 | 6% |