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Transposon identification using profile HMMs

Overview of attention for article published in BMC Genomics, February 2010
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Title
Transposon identification using profile HMMs
Published in
BMC Genomics, February 2010
DOI 10.1186/1471-2164-11-s1-s10
Pubmed ID
Authors

Paul T Edlefsen, Jun S Liu

Abstract

Transposons are "jumping genes" that account for large quantities of repetitive content in genomes. They are known to affect transcriptional regulation in several different ways, and are implicated in many human diseases. Transposons are related to microRNAs and viruses, and many genes, pseudogenes, and gene promoters are derived from transposons or have origins in transposon-induced duplication. Modeling transposon-derived genomic content is difficult because they are poorly conserved. Profile hidden Markov models (profile HMMs), widely used for protein sequence family modeling, are rarely used for modeling DNA sequence families. The algorithm commonly used to estimate the parameters of profile HMMs, Baum-Welch, is prone to prematurely converge to local optima. The DNA domain is especially problematic for the Baum-Welch algorithm, since it has only four letters as opposed to the twenty residues of the amino acid alphabet.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 13%
Brazil 2 6%
Canada 1 3%
Denmark 1 3%
Egypt 1 3%
Unknown 23 72%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 44%
Student > Ph. D. Student 5 16%
Student > Master 5 16%
Professor > Associate Professor 2 6%
Professor 1 3%
Other 3 9%
Unknown 2 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 78%
Computer Science 3 9%
Biochemistry, Genetics and Molecular Biology 1 3%
Neuroscience 1 3%
Unknown 2 6%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2014.
All research outputs
#20,656,161
of 25,374,647 outputs
Outputs from BMC Genomics
#8,709
of 11,244 outputs
Outputs of similar age
#160,546
of 174,317 outputs
Outputs of similar age from BMC Genomics
#53
of 63 outputs
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