Title |
TIP peptide inhalation in experimental acute lung injury: effect of repetitive dosage and different synthetic variants
|
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Published in |
BMC Anesthesiology, May 2014
|
DOI | 10.1186/1471-2253-14-42 |
Pubmed ID | |
Authors |
Erik K Hartmann, Rainer Thomas, Tanghua Liu, Joanna Stefaniak, Alexander Ziebart, Bastian Duenges, Daniel Eckle, Klaus Markstaller, Matthias David |
Abstract |
Inhalation of TIP peptides that mimic the lectin-like domain of TNF-α is a novel approach to attenuate pulmonary oedema on the threshold to clinical application. A placebo-controlled porcine model of acute respiratory distress syndrome (ARDS) demonstrated a reduced thermodilution-derived extravascular lung water index (EVLWI) and improved gas exchange through TIP peptide inhalation within three hours. Based on these findings, the present study compares a single versus a repetitive inhalation of a TIP peptide (TIP-A) and two alternate peptide versions (TIP-A, TIP-B). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 33% |
Other | 2 | 13% |
Student > Master | 2 | 13% |
Student > Ph. D. Student | 1 | 7% |
Student > Bachelor | 1 | 7% |
Other | 2 | 13% |
Unknown | 2 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 33% |
Medicine and Dentistry | 5 | 33% |
Immunology and Microbiology | 1 | 7% |
Energy | 1 | 7% |
Chemistry | 1 | 7% |
Other | 0 | 0% |
Unknown | 2 | 13% |