Title |
Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b
|
---|---|
Published in |
Theoretical Biology and Medical Modelling, January 2006
|
DOI | 10.1186/1742-4682-3-1 |
Pubmed ID | |
Authors |
Trevor G Marshall, Robert E Lee, Frances E Marshall |
Abstract |
There have been indications that common Angiotensin Receptor Blockers (ARBs) may be exerting anti-inflammatory actions by directly modulating the immune system. We decided to use molecular modelling to rapidly assess which of the potential targets might justify the expense of detailed laboratory validation. We first studied the VDR nuclear receptor, which is activated by the secosteroid hormone 1,25-dihydroxyvitamin-D. This receptor mediates the expression of regulators as ubiquitous as GnRH (Gonadatrophin hormone releasing hormone) and the Parathyroid Hormone (PTH). Additionally we examined Peroxisome Proliferator-Activated Receptor Gamma (PPARgamma), which affects the function of phagocytic cells, and the C-CChemokine Receptor, type 2b, (CCR2b), which recruits monocytes to the site of inflammatory immune challenge. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
Japan | 1 | <1% |
Spain | 1 | <1% |
Italy | 1 | <1% |
Unknown | 134 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 11 | 8% |
Researcher | 10 | 7% |
Professor > Associate Professor | 7 | 5% |
Student > Ph. D. Student | 7 | 5% |
Other | 6 | 4% |
Other | 11 | 8% |
Unknown | 88 | 63% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 11% |
Agricultural and Biological Sciences | 12 | 9% |
Chemistry | 7 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
Biochemistry, Genetics and Molecular Biology | 3 | 2% |
Other | 6 | 4% |
Unknown | 91 | 65% |