Title |
Induction of proline-rich tyrosine kinase 2 activation-mediated C6 glioma cell invasion after anti-vascular endothelial growth factor therapy
|
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Published in |
Journal of Translational Medicine, May 2014
|
DOI | 10.1186/1479-5876-12-148 |
Pubmed ID | |
Authors |
Cheng-Shi Xu, Ze-Fen Wang, Li-Ming Dai, Sheng-Hua Chu, Ling-Ling Gong, Ming-Huan Yang, Zhi-Qiang Li |
Abstract |
Anti-angiogenic therapy inhibits tumor growth and is considered as a potential clinical therapy for malignant glioma. However, inevitable recurrences and unexpected tumor resistance, particularly increased invasion ability of glioma cell, were observed after anti-angiogenic treatment. The underlying mechanism remains undetermined. Focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) are closely associated with cell migration; therefore, we investigated the possible role of these kinases in rat C6 glioma cell invasion induced by bevacizumab, a recombinant monoclonal antibody against vascular endothelial growth factor (VEGF). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 22% |
Student > Bachelor | 3 | 17% |
Researcher | 3 | 17% |
Student > Doctoral Student | 2 | 11% |
Student > Master | 1 | 6% |
Other | 2 | 11% |
Unknown | 3 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 4 | 22% |
Neuroscience | 3 | 17% |
Medicine and Dentistry | 3 | 17% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Computer Science | 1 | 6% |
Other | 3 | 17% |
Unknown | 2 | 11% |