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The effectiveness of antioxidant vitamins C and E in reducing myocardial infarct size in patients subjected to percutaneous coronary angioplasty (PREVEC Trial): study protocol for a pilot randomized…

Overview of attention for article published in Trials, May 2014
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Title
The effectiveness of antioxidant vitamins C and E in reducing myocardial infarct size in patients subjected to percutaneous coronary angioplasty (PREVEC Trial): study protocol for a pilot randomized double-blind controlled trial
Published in
Trials, May 2014
DOI 10.1186/1745-6215-15-192
Pubmed ID
Authors

Ramón Rodrigo, Daniel Hasson, Juan C Prieto, Gastón Dussaillant, Cristóbal Ramos, Lucio León, Javier Gárate, Nicolás Valls, Juan G Gormaz

Abstract

Acute myocardial infarction (AMI) is the leading cause of mortality worldwide. Oxidative stress has been involved in the ischemia-reperfusion injury in AMI. It has been suggested that reperfusion accounts for up to 50% of the final size of a myocardial infarct, a part of the damage likely to be prevented.Therefore, we propose that antioxidant reinforcement through vitamins C and E supplementation should protect against the ischemia-reperfusion damage, thus decreasing infarct size.The PREVEC Trial (Prevention of reperfusion damage associated with percutaneous coronary angioplasty following acute myocardial infarction) seeks to evaluate whether antioxidant vitamins C and E reduce infarct size in patients subjected to percutaneous coronary angioplasty after AMI.

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Mendeley readers

The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 1%
Australia 1 1%
Unknown 88 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 16%
Student > Bachelor 13 14%
Researcher 10 11%
Student > Ph. D. Student 7 8%
Student > Postgraduate 6 7%
Other 14 16%
Unknown 26 29%
Readers by discipline Count As %
Medicine and Dentistry 36 40%
Agricultural and Biological Sciences 7 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Social Sciences 3 3%
Economics, Econometrics and Finance 3 3%
Other 10 11%
Unknown 28 31%