Title |
Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia
|
---|---|
Published in |
Molecular Brain, May 2014
|
DOI | 10.1186/1756-6606-7-41 |
Pubmed ID | |
Authors |
Hideo Hagihara, Koji Ohira, Keizo Takao, Tsuyoshi Miyakawa |
Abstract |
Schizophrenia, a severe psychiatric disorder, has a lifetime prevalence of 1%. The exact mechanisms underlying this disorder remain unknown, though theories abound. Recent studies suggest that particular cell types and biological processes in the schizophrenic cortex have a pseudo-immature status in which the molecular properties partially resemble those in the normal immature brain. However, genome-wide gene expression patterns in the brains of patients with schizophrenia and those of normal infants have not been directly compared. Here, we show that the gene expression patterns in the schizophrenic prefrontal cortex (PFC) resemble those in the juvenile PFC. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Japan | 5 | 45% |
United Kingdom | 1 | 9% |
Unknown | 5 | 45% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 82% |
Science communicators (journalists, bloggers, editors) | 1 | 9% |
Scientists | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 1% |
Chile | 1 | 1% |
Canada | 1 | 1% |
Unknown | 71 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 20% |
Student > Ph. D. Student | 13 | 18% |
Student > Master | 11 | 15% |
Student > Doctoral Student | 7 | 9% |
Student > Bachelor | 6 | 8% |
Other | 11 | 15% |
Unknown | 11 | 15% |
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---|---|---|
Neuroscience | 20 | 27% |
Medicine and Dentistry | 12 | 16% |
Psychology | 11 | 15% |
Agricultural and Biological Sciences | 10 | 14% |
Biochemistry, Genetics and Molecular Biology | 5 | 7% |
Other | 3 | 4% |
Unknown | 13 | 18% |