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Fetal asphyctic preconditioning alters the transcriptional response to perinatal asphyxia

Overview of attention for article published in BMC Neuroscience, May 2014
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2 tweeters

Citations

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7 Dimensions

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17 Mendeley
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Title
Fetal asphyctic preconditioning alters the transcriptional response to perinatal asphyxia
Published in
BMC Neuroscience, May 2014
DOI 10.1186/1471-2202-15-67
Pubmed ID
Authors

Kimberly EM Cox-Limpens, Johan SH Vles, Daniel LA van den Hove, Luc JI Zimmermann, Antonio WD Gavilanes

Abstract

Genomic reprogramming is thought to be, at least in part, responsible for the protective effect of brain preconditioning. Unraveling mechanisms of this endogenous neuroprotection, activated by preconditioning, is an important step towards new clinical strategies for treating asphyctic neonates.Therefore, we investigated whole-genome transcriptional changes in the brain of rats which underwent perinatal asphyxia (PA), and rats where PA was preceded by fetal asphyctic preconditioning (FAPA). Offspring were sacrificed 6 h and 96 h after birth, and whole-genome transcription was investigated using the Affymetrix Gene1.0ST chip. Microarray data were analyzed with the Bioconductor Limma package. In addition to univariate analysis, we performed Gene Set Enrichment Analysis (GSEA) in order to derive results with maximum biological relevance.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 24%
Other 3 18%
Student > Master 3 18%
Student > Bachelor 2 12%
Student > Doctoral Student 1 6%
Other 2 12%
Unknown 2 12%
Readers by discipline Count As %
Medicine and Dentistry 5 29%
Agricultural and Biological Sciences 3 18%
Neuroscience 3 18%
Psychology 1 6%
Design 1 6%
Other 0 0%
Unknown 4 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 June 2014.
All research outputs
#14,781,203
of 22,756,196 outputs
Outputs from BMC Neuroscience
#654
of 1,242 outputs
Outputs of similar age
#126,662
of 226,522 outputs
Outputs of similar age from BMC Neuroscience
#16
of 27 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,242 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,522 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.