Title |
Fetal asphyctic preconditioning alters the transcriptional response to perinatal asphyxia
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Published in |
BMC Neuroscience, May 2014
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DOI | 10.1186/1471-2202-15-67 |
Pubmed ID | |
Authors |
Kimberly EM Cox-Limpens, Johan SH Vles, Daniel LA van den Hove, Luc JI Zimmermann, Antonio WD Gavilanes |
Abstract |
Genomic reprogramming is thought to be, at least in part, responsible for the protective effect of brain preconditioning. Unraveling mechanisms of this endogenous neuroprotection, activated by preconditioning, is an important step towards new clinical strategies for treating asphyctic neonates.Therefore, we investigated whole-genome transcriptional changes in the brain of rats which underwent perinatal asphyxia (PA), and rats where PA was preceded by fetal asphyctic preconditioning (FAPA). Offspring were sacrificed 6 h and 96 h after birth, and whole-genome transcription was investigated using the Affymetrix Gene1.0ST chip. Microarray data were analyzed with the Bioconductor Limma package. In addition to univariate analysis, we performed Gene Set Enrichment Analysis (GSEA) in order to derive results with maximum biological relevance. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 24% |
Other | 3 | 18% |
Student > Master | 3 | 18% |
Student > Bachelor | 2 | 12% |
Student > Doctoral Student | 1 | 6% |
Other | 2 | 12% |
Unknown | 2 | 12% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 29% |
Agricultural and Biological Sciences | 3 | 18% |
Neuroscience | 3 | 18% |
Psychology | 1 | 6% |
Design | 1 | 6% |
Other | 0 | 0% |
Unknown | 4 | 24% |