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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Absence of CX3CR1 impairs the internalization of Tau by microglia
|
|---|---|
| Published in |
Molecular Neurodegeneration, August 2017
|
| DOI | 10.1186/s13024-017-0200-1 |
| Pubmed ID | |
| Authors |
Marta Bolós, María Llorens-Martín, Juan Ramón Perea, Jerónimo Jurado-Arjona, Alberto Rábano, Félix Hernández, Jesús Avila |
| Abstract |
Extracellular Tau is toxic for neighboring cells, and it contributes to the progression of AD. The CX3CL1/CX3CR1 axis is an important neuron/microglia communication mechanism. We studied Tau clearance by microglia both in vitro (microglia primary cultures treated with Cy5-Tau, affinity chromatography to study the binding of Tau to CX3CR1, and Tau-CX3CL1 competition assays) and in vivo (stereotaxic injection of Cy5-Tau into WT and CX3CR1(-/-) mice). The expression of CX3CR1, CX3CL1 and the microglial phagocytic phenotype were studied in brain tissue samples from AD patients. Tau binding to CX3CR1 triggers the internalization of the former by microglia, whereas S396 Tau phosphorylation decreases the binding affinity of this protein to CX3CR1. Of note, the progressive increase in the levels of phosho-Tau occurred in parallel with an increase in CX3CR1. In addition, our studies suggest that the phagocytic capacity of microglia in brain tissue samples from AD patients is decreased. Furthermore, the CX3CR1/CX3CL1 axis may be impaired in late stages of the disease. Our data suggest that the CX3CR1/CX3CL1 axis plays a key role in the phagocytosis of Tau by microglia in vitro and in vivo and that it is affected as AD progresses. Taken together, our results reveal CX3CR1 as a novel target for the clearance of extracellular Tau. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 164 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 164 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 39 | 24% |
| Researcher | 17 | 10% |
| Student > Master | 14 | 9% |
| Student > Doctoral Student | 14 | 9% |
| Student > Bachelor | 13 | 8% |
| Other | 18 | 11% |
| Unknown | 49 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 42 | 26% |
| Biochemistry, Genetics and Molecular Biology | 17 | 10% |
| Agricultural and Biological Sciences | 15 | 9% |
| Immunology and Microbiology | 7 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
| Other | 22 | 13% |
| Unknown | 54 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2017.
All research outputs
#14,361,016
of 22,997,544 outputs
Outputs from Molecular Neurodegeneration
#684
of 853 outputs
Outputs of similar age
#176,080
of 316,580 outputs
Outputs of similar age from Molecular Neurodegeneration
#17
of 20 outputs
Altmetric has tracked 22,997,544 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 853 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.