Title |
Point of care platelet activity measurement in primary PCI [PINPOINT-PPCI]: a protocol paper
|
---|---|
Published in |
BMC Cardiovascular Disorders, April 2014
|
DOI | 10.1186/1471-2261-14-44 |
Pubmed ID | |
Authors |
Thomas W Johnson, Debbie Marsden, Andrew Mumford, Katie Pike, Stuart Mundell, Mark Butler, Julian W Strange, Ruth Bowles, Chris Rogers, Andreas Baumbach, Barnaby C Reeves |
Abstract |
Optimal treatment of acute ST-elevation myocardial infarction (STEMI) involves rapid diagnosis, and transfer to a cardiac centre capable of percutaneous coronary intervention (PCI) for immediate mechanical revascularisation. Successful treatment requires rapid return of perfusion to the myocardium achieved by thromboaspiration, passivation of the culprit lesion with stent scaffolding and systemic inhibition of thrombosis and platelet activation. A delicate balance exists between thrombosis and bleeding and consequently anti-thrombotic and antiplatelet treatment regimens continue to evolve. The desire to achieve reperfusion as soon as possible, in the setting of high platelet reactivity, requires potent and fast-acting anti-thrombotic/anti-platelet therapies. The associated bleeding risk may be minimised by use of short-acting anti-thrombotic intravenous agents. However, effective oral platelet inhibition is required to prevent recurrent thrombosis. The interaction between baseline platelet reactivity, timing of revascularisation and effective inhibition of thrombosis is yet to be formally investigated. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 6 | 15% |
Researcher | 5 | 12% |
Student > Ph. D. Student | 5 | 12% |
Student > Bachelor | 4 | 10% |
Student > Doctoral Student | 3 | 7% |
Other | 9 | 22% |
Unknown | 9 | 22% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 22 | 54% |
Nursing and Health Professions | 2 | 5% |
Unspecified | 1 | 2% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Agricultural and Biological Sciences | 1 | 2% |
Other | 5 | 12% |
Unknown | 9 | 22% |