Title |
Immunohistochemical assessment of a unique basal pattern of p53 expression in ulcerative-colitis-associated neoplasia using computer-assisted cytometry
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Published in |
Diagnostic Pathology, May 2014
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DOI | 10.1186/1746-1596-9-99 |
Pubmed ID | |
Authors |
Shunsuke Kobayashi, Takahiro Fujimori, Hiroyuki Mitomi, Shigeki Tomita, Kazuhito Ichikawa, Johji Imura, Shigehiko Fujii, Michihiro Itabashi, Shingo Kameoka, Yoshinori Igarashi |
Abstract |
The basal pattern of p53 expression, defined as its immunoreactivity confined to the basal half of the glands, is associated with early neoplastic lesions in ulcerative colitis (UC). However, their clinical utility of this finding is limited by the use of "visual estimation" (approximate immunoreactivity on the basis of scanning the stained slide, without formal counting). This study was designed to analyze the basal pattern of p53 using computer-assisted cytometry and to identify the optimal cutoff value for discriminating between UC-associated early-stage neoplasia and regenerative atypia. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 24% |
Researcher | 7 | 21% |
Student > Postgraduate | 3 | 9% |
Lecturer | 2 | 6% |
Student > Master | 2 | 6% |
Other | 3 | 9% |
Unknown | 9 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 44% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Immunology and Microbiology | 2 | 6% |
Computer Science | 1 | 3% |
Psychology | 1 | 3% |
Other | 3 | 9% |
Unknown | 10 | 29% |