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Immunohistochemical assessment of a unique basal pattern of p53 expression in ulcerative-colitis-associated neoplasia using computer-assisted cytometry

Overview of attention for article published in Diagnostic Pathology, May 2014
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Title
Immunohistochemical assessment of a unique basal pattern of p53 expression in ulcerative-colitis-associated neoplasia using computer-assisted cytometry
Published in
Diagnostic Pathology, May 2014
DOI 10.1186/1746-1596-9-99
Pubmed ID
Authors

Shunsuke Kobayashi, Takahiro Fujimori, Hiroyuki Mitomi, Shigeki Tomita, Kazuhito Ichikawa, Johji Imura, Shigehiko Fujii, Michihiro Itabashi, Shingo Kameoka, Yoshinori Igarashi

Abstract

The basal pattern of p53 expression, defined as its immunoreactivity confined to the basal half of the glands, is associated with early neoplastic lesions in ulcerative colitis (UC). However, their clinical utility of this finding is limited by the use of "visual estimation" (approximate immunoreactivity on the basis of scanning the stained slide, without formal counting). This study was designed to analyze the basal pattern of p53 using computer-assisted cytometry and to identify the optimal cutoff value for discriminating between UC-associated early-stage neoplasia and regenerative atypia.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 24%
Researcher 7 21%
Student > Postgraduate 3 9%
Lecturer 2 6%
Student > Master 2 6%
Other 3 9%
Unknown 9 26%
Readers by discipline Count As %
Medicine and Dentistry 15 44%
Biochemistry, Genetics and Molecular Biology 2 6%
Immunology and Microbiology 2 6%
Computer Science 1 3%
Psychology 1 3%
Other 3 9%
Unknown 10 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2014.
All research outputs
#18,372,841
of 22,756,196 outputs
Outputs from Diagnostic Pathology
#758
of 1,122 outputs
Outputs of similar age
#163,011
of 226,522 outputs
Outputs of similar age from Diagnostic Pathology
#26
of 35 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,122 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,522 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.