Title |
Aldehyde dehydrogenase and estrogen receptor define a hierarchy of cellular differentiation in the normal human mammary epithelium
|
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Published in |
Breast Cancer Research, May 2014
|
DOI | 10.1186/bcr3663 |
Pubmed ID | |
Authors |
Gabriella Honeth, Sara Lombardi, Christophe Ginestier, Minhee Hur, Rebecca Marlow, Bharath Buchupalli, Ireneusz Shinomiya, Patrycja Gazinska, Silvia Bombelli, Vernie Ramalingam, Anand D Purushotham, Sarah E Pinder, Gabriela Dontu |
Abstract |
Although estrogen and progesterone play a key role in normal mammary development and in breast cancer, the potential for proliferation and lineage differentiation as well as origin of cells that express the estrogen receptor (ER) in normal breast epithelium are not known. Some evidence suggests that normal human mammary stem/progenitor cells are ER-, but the identity of these cells and the cellular hierarchy of breast epithelium are still subjects of controversy. It is likely that elucidation of these aspects will bring insight into the cellular origin of breast cancer subtypes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Unknown | 57 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 17% |
Student > Ph. D. Student | 8 | 14% |
Student > Bachelor | 6 | 10% |
Student > Doctoral Student | 5 | 9% |
Other | 4 | 7% |
Other | 14 | 24% |
Unknown | 11 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 29% |
Biochemistry, Genetics and Molecular Biology | 16 | 28% |
Medicine and Dentistry | 10 | 17% |
Nursing and Health Professions | 1 | 2% |
Chemical Engineering | 1 | 2% |
Other | 2 | 3% |
Unknown | 11 | 19% |