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Estrogen promotes stemness and invasiveness of ER-positive breast cancer cells through Gli1 activation

Overview of attention for article published in Molecular Cancer, June 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

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7 X users

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76 Mendeley
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Title
Estrogen promotes stemness and invasiveness of ER-positive breast cancer cells through Gli1 activation
Published in
Molecular Cancer, June 2014
DOI 10.1186/1476-4598-13-137
Pubmed ID
Authors

Ying Sun, Yunshan Wang, Cong Fan, Peng Gao, Xiuwen Wang, Guangwei Wei, Junmin Wei

Abstract

Although long-term estrogen (E2) exposure is associated with increased breast cancer (BC) risk, and E2 appears to sustain growth of BC cells that express functional estrogen receptors (ERs), its role in promoting BC stem cells (CSCs) remains unclear. Considering that Gli1, part of the Sonic hedgehog (Shh) developmental pathway, has been shown to mediate CSCs, we investigated whether E2 and Gli1 could promote CSCs and epithelial-mesenchymal transition (EMT) in ER+ BC cell lines.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 1 1%
Brazil 1 1%
Unknown 74 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 21%
Researcher 15 20%
Student > Master 11 14%
Student > Bachelor 6 8%
Student > Doctoral Student 4 5%
Other 10 13%
Unknown 14 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 28%
Biochemistry, Genetics and Molecular Biology 16 21%
Medicine and Dentistry 14 18%
Engineering 2 3%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 3 4%
Unknown 18 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2014.
All research outputs
#7,444,323
of 22,756,196 outputs
Outputs from Molecular Cancer
#546
of 1,718 outputs
Outputs of similar age
#73,493
of 227,901 outputs
Outputs of similar age from Molecular Cancer
#15
of 49 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,718 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,901 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.