Title |
Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age
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Published in |
World Journal of Surgical Oncology, August 2017
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DOI | 10.1186/s12957-017-1222-4 |
Pubmed ID | |
Authors |
Xuan Jiang, Jiaxin Yang, Mei Yu, Weimin Xie, Dongyan Cao, Ming Wu, Lingya Pan, Huifang Huang, Yan You, Keng Shen |
Abstract |
Fertility-sparing surgery is indicated for patients with stage I epithelial ovarian cancers. We sought to evaluate the clinical outcomes and oncofertility in a cohort of patients of reproductive age with stage I epithelial ovarian cancer (EOC). Overall, 108 patients of reproductive age (≤ 40 years) diagnosed with stage I EOC who were treated at Peking Union Medical College Hospital between 1999 and 2013 were included in the study. The Kaplan-Meier model and Cox regression analyses were used for the survival analysis. The type of surgery included fertility-sparing surgery (FSS) (48.1%) and radical surgery (RS) (51.9%). After a median follow-up of 83 months, we observed that grade 3 or clear-cell carcinoma was the only independent risk factor for disease-free survival and tumor-specific survival in the multivariate analysis. Patients with grade 3 or clear-cell carcinoma tended to be older than 30 years, have endometriosis, and undergo RS (p < 0.05). Fertility-sparing surgery did not affect disease-free survival or tumor-specific survival among patients of reproductive age with stage I EOC and among high-risk patients with stage IC2-3, grade 3, or clear-cell carcinoma. Thirty-four out of 52 (65.4%) FSS patients attempted to get pregnant. Twenty-eight (82.4%) achieved a successful pregnancy with a full-term delivery. Grade 3 or clear-cell carcinoma was the only independent risk factor for survival of patients of reproductive age with stage I EOC. FSS can be safely performed on patients of reproductive age with grade 1-2, stage I EOC. The safety of FSS for grade 3 and clear-cell carcinoma warrants further investigation. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 7 | 19% |
Student > Doctoral Student | 5 | 14% |
Student > Bachelor | 4 | 11% |
Student > Master | 4 | 11% |
Student > Postgraduate | 4 | 11% |
Other | 6 | 16% |
Unknown | 7 | 19% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 20 | 54% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Nursing and Health Professions | 2 | 5% |
Chemical Engineering | 1 | 3% |
Psychology | 1 | 3% |
Other | 1 | 3% |
Unknown | 10 | 27% |