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Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes

Overview of attention for article published in Arthritis Research & Therapy, May 2014
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Title
Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes
Published in
Arthritis Research & Therapy, May 2014
DOI 10.1186/ar4564
Pubmed ID
Authors

Fatima Ezzahra El Mansouri, Salwa-Sarah Nebbaki, Mohit Kapoor, Hassan Afif, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Mohamed Benderdour, Hassan Fahmi

Abstract

Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes the terminal step in the biosynthesis of PGE2, a critical mediator in the pathophysiology of osteoarthritis (OA). Histone methylation plays an important role in epigenetic gene regulation. In this study, we investigated the roles of histone H3 (H3K9) methylation in interleukin-1beta (IL-1beta)-induced mPGES-1 expression in human chondrocytes.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
United States 1 3%
Unknown 31 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 18%
Researcher 5 15%
Student > Ph. D. Student 4 12%
Other 3 9%
Student > Doctoral Student 3 9%
Other 5 15%
Unknown 7 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 21%
Agricultural and Biological Sciences 7 21%
Medicine and Dentistry 2 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Immunology and Microbiology 1 3%
Other 4 12%
Unknown 11 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 June 2014.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Arthritis Research & Therapy
#3,132
of 3,381 outputs
Outputs of similar age
#209,211
of 241,958 outputs
Outputs of similar age from Arthritis Research & Therapy
#35
of 40 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,958 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.