Title |
Identification of G protein-coupled receptors in Schistosoma haematobium and S. mansoni by comparative genomics
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Published in |
Parasites & Vectors, May 2014
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DOI | 10.1186/1756-3305-7-242 |
Pubmed ID | |
Authors |
Tulio D L Campos, Neil D Young, Pasi K Korhonen, Ross S Hall, Stefano Mangiola, Andrew Lonie, Robin B Gasser |
Abstract |
Schistosomiasis is a parasitic disease affecting ~200 million people worldwide. Schistosoma haematobium and S. mansoni are two relatively closely related schistosomes (blood flukes), and the causative agents of urogenital and hepatointestinal schistosomiasis, respectively. The availability of genomic, transcriptomic and proteomic data sets for these two schistosomes now provides unprecedented opportunities to explore their biology, host interactions and schistosomiasis at the molecular level. A particularly important group of molecules involved in a range of biological and developmental processes in schistosomes and other parasites are the G protein-coupled receptors (GPCRs). Although GPCRs have been studied in schistosomes, there has been no detailed comparison of these receptors between closely related species. Here, using a genomic-bioinformatic approach, we identified and characterised key GPCRs in S. haematobium and S. mansoni (two closely related species of schistosome). |
X Demographics
Geographical breakdown
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 2% |
Canada | 1 | 2% |
Australia | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 52 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 15 | 27% |
Researcher | 9 | 16% |
Student > Master | 7 | 13% |
Professor > Associate Professor | 4 | 7% |
Student > Bachelor | 4 | 7% |
Other | 5 | 9% |
Unknown | 12 | 21% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 18 | 32% |
Biochemistry, Genetics and Molecular Biology | 10 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Veterinary Science and Veterinary Medicine | 3 | 5% |
Environmental Science | 1 | 2% |
Other | 3 | 5% |
Unknown | 18 | 32% |