Title |
An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial
|
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Published in |
Trials, June 2014
|
DOI | 10.1186/1745-6215-15-199 |
Pubmed ID | |
Authors |
Robert M LāE Orme, Gavin D Perkins, Daniel F McAuley, Kathleen D Liu, Alexina J Mason, Andrea Morelli, Mervyn Singer, Deborah Ashby, Anthony C Gordon |
Abstract |
Organ dysfunction consequent to infection ('severe sepsis') is the leading cause of admission to an intensive care unit (ICU). In both animal models and early clinical studies the calcium channel sensitizer levosimendan has been demonstrated to have potentially beneficial effects on organ function. The aims of the Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS) trial are to identify whether a 24-hour infusion of levosimendan will improve organ dysfunction in adults who have septic shock and to establish the safety profile of levosimendan in this group of patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 8 | 42% |
Norway | 1 | 5% |
United States | 1 | 5% |
Unknown | 9 | 47% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 53% |
Practitioners (doctors, other healthcare professionals) | 5 | 26% |
Science communicators (journalists, bloggers, editors) | 2 | 11% |
Scientists | 2 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | <1% |
Unknown | 109 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 23 | 21% |
Student > Master | 13 | 12% |
Student > Bachelor | 11 | 10% |
Student > Ph. D. Student | 9 | 8% |
Student > Postgraduate | 7 | 6% |
Other | 21 | 19% |
Unknown | 26 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 50 | 45% |
Nursing and Health Professions | 13 | 12% |
Agricultural and Biological Sciences | 7 | 6% |
Biochemistry, Genetics and Molecular Biology | 2 | 2% |
Psychology | 2 | 2% |
Other | 8 | 7% |
Unknown | 28 | 25% |