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An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial

Overview of attention for article published in Trials, June 2014
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Title
An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial
Published in
Trials, June 2014
DOI 10.1186/1745-6215-15-199
Pubmed ID
Authors

Robert M Lā€™E Orme, Gavin D Perkins, Daniel F McAuley, Kathleen D Liu, Alexina J Mason, Andrea Morelli, Mervyn Singer, Deborah Ashby, Anthony C Gordon

Abstract

Organ dysfunction consequent to infection ('severe sepsis') is the leading cause of admission to an intensive care unit (ICU). In both animal models and early clinical studies the calcium channel sensitizer levosimendan has been demonstrated to have potentially beneficial effects on organ function. The aims of the Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS) trial are to identify whether a 24-hour infusion of levosimendan will improve organ dysfunction in adults who have septic shock and to establish the safety profile of levosimendan in this group of patients.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 <1%
Unknown 109 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 23 21%
Student > Master 13 12%
Student > Bachelor 11 10%
Student > Ph. D. Student 9 8%
Student > Postgraduate 7 6%
Other 21 19%
Unknown 26 24%
Readers by discipline Count As %
Medicine and Dentistry 50 45%
Nursing and Health Professions 13 12%
Agricultural and Biological Sciences 7 6%
Biochemistry, Genetics and Molecular Biology 2 2%
Psychology 2 2%
Other 8 7%
Unknown 28 25%