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X Demographics
Mendeley readers
Attention Score in Context
| Title |
What makes gouty inflammation so variable?
|
|---|---|
| Published in |
BMC Medicine, August 2017
|
| DOI | 10.1186/s12916-017-0922-5 |
| Pubmed ID | |
| Authors |
Robert Terkeltaub |
| Abstract |
Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem. Flares can be complex and expensive to treat, partly due to the frequent comorbidities. Unmet needs in gout management are more pressing given the markedly increasing gout flare hospital admission rates. In addition, chronic gouty arthritis can cause joint damage and functional impairment. This review addresses new knowledge on the basis for the marked, inherent variability of responses to deposited urate crystals, including the unpredictable and self-limited aspects of many gout flares. Specific topics reviewed include how innate immunity and two-signal inflammasome activation intersect with diet, metabolism, nutritional biosensing, the microbiome, and the phagocyte cytoskeleton and cell fate. The paper discusses the roles of endogenous constitutive regulators of inflammation, including certain nutritional biosensors, and emerging genetic and epigenetic factors. Recent advances in the basis of variability in responses to urate crystals in gout provide information about inflammatory arthritis, and have identified potential new targets and strategies for anti-inflammatory prevention and treatment of gouty arthritis. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 25% |
| United Kingdom | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 105 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 11% |
| Student > Ph. D. Student | 11 | 10% |
| Student > Bachelor | 11 | 10% |
| Researcher | 9 | 9% |
| Other | 7 | 7% |
| Other | 16 | 15% |
| Unknown | 39 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 20% |
| Biochemistry, Genetics and Molecular Biology | 10 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 7% |
| Nursing and Health Professions | 6 | 6% |
| Agricultural and Biological Sciences | 6 | 6% |
| Other | 10 | 10% |
| Unknown | 45 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2019.
All research outputs
#13,803,679
of 23,393,513 outputs
Outputs from BMC Medicine
#2,893
of 3,525 outputs
Outputs of similar age
#162,737
of 319,768 outputs
Outputs of similar age from BMC Medicine
#40
of 51 outputs
Altmetric has tracked 23,393,513 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,525 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 44.5. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,768 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.