Title |
Transcriptomic analysis supports similar functional roles for the two thymuses of the tammar wallaby
|
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Published in |
BMC Genomics, August 2011
|
DOI | 10.1186/1471-2164-12-420 |
Pubmed ID | |
Authors |
Emily SW Wong, Anthony T Papenfuss, Andreas Heger, Arthur L Hsu, Chris P Ponting, Robert D Miller, Jane C Fenelon, Marilyn B Renfree, Richard A Gibbs, Katherine Belov |
Abstract |
The thymus plays a critical role in the development and maturation of T-cells. Humans have a single thoracic thymus and presence of a second thymus is considered an anomaly. However, many vertebrates have multiple thymuses. The tammar wallaby has two thymuses: a thoracic thymus (typically found in all mammals) and a dominant cervical thymus. Researchers have known about the presence of the two wallaby thymuses since the 1800s, but no genome-wide research has been carried out into possible functional differences between the two thymic tissues. Here, we used pyrosequencing to compare the transcriptomes of a cervical and thoracic thymus from a single 178 day old tammar wallaby. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Demographic breakdown
Readers by professional status | Count | As % |
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Other | 0 | 0% |
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