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Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity

Overview of attention for article published in Radiation Oncology, August 2011
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Title
Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity
Published in
Radiation Oncology, August 2011
DOI 10.1186/1748-717x-6-96
Pubmed ID
Authors

Jufang Wang, Fengtao Su, Lubomir B Smilenov, Libin Zhou, Wentao Hu, Nan Ding, Guangming Zhou

Abstract

Both epidemiological and experimental studies suggest that heterozygosity for a single gene is linked with tumorigenesis and heterozygosity for two genes increases the risk of tumor incidence. Our previous work has demonstrated that Atm/Brca1 double heterozygosity leads to higher cell transformation rate than single heterozygosity. However, the underlying mechanisms have not been fully understood yet. In the present study, a series of pathways were investigated to clarify the possible mechanisms of increased risk of tumorigenesis in Atm and Brca1 heterozygosity.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 23%
Student > Ph. D. Student 4 18%
Professor > Associate Professor 2 9%
Professor 2 9%
Other 1 5%
Other 2 9%
Unknown 6 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 23%
Agricultural and Biological Sciences 5 23%
Medicine and Dentistry 2 9%
Nursing and Health Professions 1 5%
Physics and Astronomy 1 5%
Other 1 5%
Unknown 7 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2011.
All research outputs
#15,233,109
of 22,649,029 outputs
Outputs from Radiation Oncology
#1,035
of 2,040 outputs
Outputs of similar age
#86,426
of 123,290 outputs
Outputs of similar age from Radiation Oncology
#8
of 11 outputs
Altmetric has tracked 22,649,029 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,040 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 123,290 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.