Title |
Macrophage activation state determines the response to rhinovirus infection in a mouse model of allergic asthma
|
---|---|
Published in |
Respiratory Research, June 2014
|
DOI | 10.1186/1465-9921-15-63 |
Pubmed ID | |
Authors |
Jun Young Hong, Yutein Chung, Jessica Steenrod, Qiang Chen, Jing Lei, Adam T Comstock, Adam M Goldsmith, J Kelley Bentley, Uma S Sajjan, Marc B Hershenson |
Abstract |
The mechanisms by which viruses cause asthma exacerbations are not precisely known. Previously, we showed that, in ovalbumin (OVA)-sensitized and -challenged mice with allergic airway inflammation, rhinovirus (RV) infection increases type 2 cytokine production from alternatively-activated (M2) airway macrophages, enhancing eosinophilic inflammation and airways hyperresponsiveness. In this paper, we tested the hypothesis that IL-4 signaling determines the state of macrophage activation and pattern of RV-induced exacerbation in mice with allergic airways disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Korea, Republic of | 1 | 2% |
Chile | 1 | 2% |
Unknown | 40 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 26% |
Student > Master | 6 | 14% |
Student > Bachelor | 6 | 14% |
Student > Doctoral Student | 4 | 10% |
Researcher | 4 | 10% |
Other | 8 | 19% |
Unknown | 3 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 26% |
Immunology and Microbiology | 9 | 21% |
Agricultural and Biological Sciences | 6 | 14% |
Biochemistry, Genetics and Molecular Biology | 5 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 5 | 12% |
Unknown | 5 | 12% |